The manor dates to Domesday, was later granted a licence by Edward VI and was owned by the estate of House of Carthusian monks: Priory of Sheen in Surrey.
At the "Dissolution of the Monasteries" (1536-1541) the Manor of Sheen was leased to Robert Chester, who in 1550 acquired the manor through an exchange with the Crown. In 1554 he sold Sheene manor to a George Gill, who had been succeeded by John Gill, presumably his son, by 1569. In 1576 John sold the manor to Thomas Sterne. and it descended with the lease of Melbourn Bury in Melbourn to Sterne's daughter Catherine and her husband Sir William Ayloffe.